Nomenclature
Short Name:
ADCK5
Full Name:
AarF domain containing kinase 5
Alias:
- AL580712
Classification
Type:
Protein-serine/threonine kinase
Group:
Atypical
Family:
ABC1
SubFamily:
ABC1-B
Structure
Mol. Mass (Da):
65897
# Amino Acids:
580
# mRNA Isoforms:
1
mRNA Isoforms:
65,897 Da (580 AA; Q3MIX3)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Serine phosphorylated:
S359.
Threonine phosphorylated:
T354.
Tyrosine phosphorylated:
Y353, Y520, Y524.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
100
2038
6
1038
3
70
4
25
-
-
-
-
7
151
32
498
35
723
11
564
0.4
9
9
9
1
24
13
12
3
63
5
68
4
75
3
2
1
24
29
26
5
94
5
73
34
691
11
586
-
-
-
-
2
34
3
1
3
67
5
55
3
52
5
23
2
35
84
30
1
28
3
4
0.6
12
21
5
24
490
31
328
3
67
5
77
5
112
5
97
-
-
-
-
2
31
3
3
8
155
5
128
31
633
19
592
2
38
3
5
2
36
3
6
2
43
3
5
4
72
14
24
61
1248
12
64
49
993
11
3066
0.2
4
12
1
36
728
26
628
2
39
22
24
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
99.7
99.7
100
34.5
51.7
97
-
-
92
-
-
-
77.1
83.3
83
-
-
-
80.6
89
81
79.4
88.1
80
-
-
-
56.2
63.8
-
32.2
49.7
-
32.9
51.5
-
60.5
76.5
61
-
-
-
39
57.2
49
-
-
-
-
-
-
41.4
60.5
-
-
-
-
-
-
-
-
-
-
32.8
51.7
-
25.2
45.9
-
-
-
33
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for ADCK5 in diverse human cancers of 964, which is 2.1-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 11 for this protein kinase in human cancers was 0.2-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.05 % in 24726 diverse cancer specimens. This rate is only -37 % lower than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.16 % in 1270 large intestine cancers tested; 0.09 % in 589 stomach cancers tested.
Frequency of Mutated Sites:
None >1 in 19643 cancer specimens
Comments:
Only 1 deletion, and no insertions or complex mutations are noted on the COSMIC website.