Nomenclature
Short Name:
SgK071
Full Name:
Hypothetical protein C9orf96
Alias:
- C9orf96
- AL044935
Classification
Type:
Protein-serine/threonine kinase
Group:
Other
Family:
Other-Unique
SubFamily:
NA
Structure
Mol. Mass (Da):
75676
# Amino Acids:
680
# mRNA Isoforms:
3
mRNA Isoforms:
75,676 Da (680 AA; Q8NE28); 22,990 Da (213 AA; Q8NE28-2); 22,767 Da (213 AA; Q8NE28-3)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 28 | 297 | Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Acetylated:
K337.
Serine phosphorylated:
S177, S178.
Threonine phosphorylated:
T183, T295.
Tyrosine phosphorylated:
Y624.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
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Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
90.1
90.8
99
20.2
37
89
-
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68
-
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63
75.7
72
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58
74.7
62
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59
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23.6
39.1
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39
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33
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24.8
42.7
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For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.05 % in 24433 diverse cancer specimens. This rate is only -28 % lower than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.3 % in 589 stomach cancers tested; 0.22 % in 864 skin cancers tested; 0.22 % in 1270 large intestine cancers tested; 0.15 % in 603 endometrium cancers tested; 0.12 % in 127 biliary tract cancers tested; 0.11 % in 548 urinary tract cancers tested; 0.1 % in 441 autonomic ganglia cancers tested; 0.09 % in 1634 lung cancers tested; 0.06 % in 1512 liver cancers tested; 0.05 % in 273 cervix cancers tested; 0.05 % in 1276 kidney cancers tested; 0.04 % in 833 ovary cancers tested; 0.04 % in 710 oesophagus cancers tested; 0.04 % in 2082 central nervous system cancers tested; 0.03 % in 881 prostate cancers tested; 0.03 % in 558 thyroid cancers tested; 0.02 % in 1316 breast cancers tested; 0.01 % in 2009 haematopoietic and lymphoid cancers tested.
Frequency of Mutated Sites:
None > 6 in 20,010 cancer specimens
Comments:
Only 3 deletions, and no insertions or complex mutations are noted on the COSMIC website.